The Pisidia region, in eastern Asia Minor in which Antioch resided, was known in the first century as an unsafe part of the Roman Empire in which to travel. Paul, when writing to the Corinthians regarding how much he had endured as a servant of God, writes that he was at times "in perils of robbers" (2Corinthians 11:26) while serving the churches.
Conybeare and Howson's excellent book on the life of Paul states the following regarding Antioch and its surrounding area.
"The lawless and marauding habits of the population of those mountains (in Eastern Asia Minor) . . . were notorious in all parts of ancient history . . . No population through the midst of which Apostle Paul ever traveled, abounded more in those "perils of robbers," of which he himself speaks, than the wild and lawless clans of the Pisidian Highlanders (The Life and Epistles of Apostle Paul, Chapter 6)
Asia Minor's Antioch is the only place recorded in the New Testament where women (upper-class women in particular) are specifically mentioned as fully participating in the persecution of Christians (Acts 13:50).
The church in Antioch was started by the Apostle Paul. He first evangelized the city sometime in 45 A.D. (Acts 13:14), then came back to it a few months later (Acts 14:21), visited it again in 50 A.D. (Acts 16:6), then one last time in 53 A.D. (Acts 18:23).
Iconium was the ancient capital city of the Asia Minor region known as Lycaonia, which itself was part of the Roman province named Galatia. It was a wealthy town located in a well-watered, fertile region along the Roman road called the Via Sebaste.
The Apostle Paul visited Iconium in his first, second and third missionary journeys and founded the city's Christian church. He refers to the trials and troubles he had in preaching the gospel in the city when he writes the following to fellow evangelist Timothy.
Persecutions and sufferings - such as happened to me in Antioch, in Iconium, and in Lystra. You know what sort of persecutions I endured; and the Lord delivered me out of them all. And indeed, everyone who desires to live godly in Christ Jesus shall be persecuted. (2Timothy 3:11 - 12, HBFV).