Temple ruins dedicated to Emperor Augustus
Pisidian Antioch (so named to differentiate it from a city with the same name in Syria) was a city in the ancient province of Phrygia. It's modern location is in the west-central part of Turkey, which is relatively close to the Pisidian border. Seleucus I Nicator (one of Alexander the Great's generals and the founder of the Seleucid Dynasty of rule) ruled the city sometime after 323 B.C. In 189, after the peace with Antiochus the Great, the Romans made the location a 'free city.' The Romans took over total control of the city in 25 B.C. Antioch was made a colony of the Romans under Emperor Augustus around 6 B.C. It became a military colony and a center of civil administration centers in the region.
It is just before Paul visits Pisidian Antioch during his first missionary journey that fellow evangelist and gospel writer John Mark abruptly decides (for reasons not delineated in the Bible) to return to Jerusalem (Acts 13:13). His departure will later become a catalyst for Paul and Barnabas splitting up before the apostle's second missionary journey.
35. Now Paul and Barnabas were staying in (Syrian) Antioch with many others, teaching and preaching the gospel - the Word of the Lord. 36. And after certain days, Paul said to Barnabas, "Let us go back to see how our brethren are doing in every city where we have preached the Word of the Lord." 37. And Barnabas was determined to take with them John who was called Mark (John Mark and Barnabas were cousins); 38. But Paul did not think it good to take him because he had departed from them at Pamphylia, and did not go with them to the work.
39. As a result, such a sharp contention arose between them that they parted from one another. And Barnabas took Mark and sailed to Cyprus; 40. But Paul chose Silas and departed, after being committed to the grace of God by the brethren (Acts 15:35 - 40, HBFV).
It was during his second journey, just before visiting Antioch, that Paul met a new traveling companion named Timothy. Raised in a Bible-believing family (2Timothy 1:5) Timothy would become a valuable aid in spreading the gospel and eventually become Paul's most trusted friend. He would be with the apostle Paul until the very end when he was martyred by the Romans.
The city and its environs, in Paul's day, was notorious for its many robbers. This may have been one of the places Paul alludes to when he lists, in the book of 2Corinthians, some of the trials and troubles he experienced while preaching.
23. Are they servants of Christ? (I am speaking as if I were out of my mind.) So am I, above and beyond measure - in labors more abundant, in stripes above measure, in imprisonments more frequent, in deaths often.
4. Five times from the Jews I received forty stripes less one. 25. Three times I was beaten with rods; once I was stoned; three times I was shipwrecked; a night and a day I spent in the deep. 26. I have been in journeyings often, in perils of rivers, IN PERILS OF ROBBERS, in perils from my own race, in perils from the Gentiles, in perils in the city, in perils in the desert, in perils on the sea, in perils among false brethren;
27. In weariness and painfulness, in watchings often, in hunger and thirst, in fastings often, in cold and nakedness (2Corinthians 11:23 - 27).
Paul visited Antioch at least three times during his ministry (first, second and third missionary journeys).