Petra is perhaps the most popular location often referred to as a (or the) place of safety. Some translations of the Bible mention the location by name in their text, such as the Douay-Rheims (Isaiah 16:1, 42:1), The Living Bible (Jeremiah 49:16) and the Vulgate (Judges 1:36). It was once the capital of Arabia Petraea. Today, however, Petra is a largely inhospitable, and almost uninhabitable, valley near Jerusalem.
The initial concept of a "place of safety" in the Bible came from Old Testament law. God commanded the Israelites to set aside six cities of refuge (Bezer, Golan, Hebron, Kedesh, Ramoth-Gilead, and Shechem) in the Promised Land for the purpose of protecting someone who accidently killed another human. These cities were to insure a person had their ‘day in court’ and not killed himself or herself out of revenge.
12. And they shall be to you cities for refuge from the avenger so that the manslayer does not die until he stands before the congregation in judgment (Numbers 35:12, HBFV)