Paul arrives in Jerusalem around late spring of 58 A.D., possibly near the time of the Feast of Pentecost (Acts 21:17).

Arriving in Jerusalem Paul visits James (Acts 21:18) and soon afterwards goes to the temple with four Jewish converts (Acts 21:23-26). Jews from Asia who hate Paul, believing he has brought a Gentile into the Temple area, cause a riot (Acts 21:27-30). Roman troops hear of the tumult and race to the scene, saving Paul from certain death (Acts 21:31-32). They take Paul away and decide to scourge him to find out what crime(s) he committed that so enraged the people. Paul is saved from being scourged, however, when the chief captain learns he is a Roman citizen (Acts 22:25-29). Paul's defense of himself the next day before the Sanhedrin (Acts 23:1-10) accomplishes little. He is soon escorted out of the city by Roman soldiers, at night, so that he wouldn't be killed (Acts 23:12-23). The soldiers take Paul to Felix in Caesarea, who is the Roman governor of Judea, so that he can decide Paul's fate (Acts 23:24-35). When Paul arrives in Caesarea Felix decides to keep him in the Praetorium of Herod (Acts 23:35).

Paul is a Roman prisoner in Caesarea from early Summer 58 A.D. to early Autumn 60 A.D.

In Caesarea Paul defends himself three times while he is a prisoner. He is found to have done nothing worthy of bonds or death. Festus replaces Felix as Roman governor of Judea and hears Paul case.

Paul, as a Roman citizen, requests from Festus that his case be heard by Caesar. Festus agrees to send Paul to Rome. King Agrippa (the son of King Herod Agrippa who in Acts 12:1 in killed by the Angel of the Lord) and his wife arrive in Caesarea and allow Paul to defend himself against the charges laid against him. (Acts 25:13-26:29). Like Festus Agrippa also finds that, in spite of the accusations against him, Paul has done nothing worthy of imprisonment or even death (Acts 26;30-31). However, since Paul has appealed his case to Caesar, Agrippa agrees to send Paul to Rome (Acts 26:32).

In the Autumn of 60 A.D. Paul, along with other prisoners, boards a boat for Rome. Paul's travel to Rome is considered by many to be his final or last missionary journey.

The prisoners are escorted on their journey to Rome by a Roman Centurion named Julius (Acts 27:1-2). After stopping in several cities along the way, Paul and company make their way to the Isle of Crete (Acts 27:7). Although Paul warns Julius not to sail the Mediterranean during a dangerous time of the year (September to October), the Centurion disregards his advice and sets sail from Crete (Acts 27:9-12). The ship encounters a fierce storm along the way and is shipwrecked near the island of Malta (Acts 27:14 - 28:1). All those on the ship either swim or grab boards from the wreck and successfully make their way to the island. After staying three months Paul and company set sail again for Rome. He eventually arrives in the Italian port city of Puteoli (Acts 28:13), where he stays for one week with Christians in the area. Paul is then taken to Rome via the well-known Appian Way road (Acts 28:14-16).

In Rome the Centurion delivers Paul to the captain of the guard. Paul is allowed to live by himself guarded only by a soldier (Acts 28:16). While in Rome Paul is able to receive visitors and continue his preaching of the Gospel (Acts 28:17-31).

In the Spring of 63 A.D. Paul is acquitted of the charges against him. He travels from Rome to the isle of Crete (Titus 1:5).

Paul leaves Titus in Crete and goes to Nicopolis in Macedonia (Titus 3:12). From Nicopolis Paul writes the book of 1Timothy and Titus.

Paul possibly travels to Spain and Britain (see Romans 15:28).

Paul is back in Roman prison in 67 A.D. and writes 2Timothy. This letter to his close friend, traveling companion and fellow laborer in spreading the gospel would be his last epistle.

Paul's death and martyrdom likely occurs in May or June of 68 A.D. Roman emperor Nero dies on June 9, 68 A.D. in Greece.