Bible Meaning: Not in the Bible
Biblical cites on or having a water connection to the Aegean Sea includes Cenchrea, Thessalonica (located on the Thermaic Gulf), Neapolis, Troas, Assos, Ephesus, Miletus and Cnidus. Islands considered within the sea include Samothrace, Lesbos, Chios, Samos, Patmos, Cos and Rhodes.
Paul, during his second, third and fourth missionary journeys, used the natural highway of the Aegean several times.
Second Missionary Journey
Paul sailed from Troas, located on the eastern side of the sea, to Neapolis in Macedonia (Acts 16:11). The Aegean enabled the apostle to be the first person to establish Christian churches on the European continent.
Paul later sailed from a port near Berea to Athens (Acts 17:14 - 15) where he preached the gospel to the city's people and pagan philosophers.
Towards the end of his journey the apostle sails the Aegean from Cenchrea to Ephesus (Acts 18:18 - 19), then later uses part of it from Ephesus to his final destination in Judea (verses 21 - 22).
Third Missionary Journey
Paul again uses the Aegean to sail from Troas to Neapolis. After visiting churches in Macedonia and Achaia he journeys by ship back to Troas (Acts 20:1, 5 - 6). After catching a ship in Assos, he uses the sea to transport himself to Tyre in Syria (20:14 - 21:3).
Fourth Missionary Journey
Paul, as a prisoner of Rome, is taken on a ship past the Aegean Sea island of Rhodes and the port of Cnidus before heading south toward Crete due to the weather (Acts 27:6 - 7).