Alexander III, son of Greek King Philip of Macedon, is better known with his nickname "the Great." Born in 356 B.C. he is considered by most historians to be one of, if not THE, best commanders of the military throughout history. Alexander, who was never defeated in battle, controlled a vast empire that spanned most of the known world by the time of his death in 323 B.C. at age 33.
After his father had unified the many states in Greece, Alexander (who ruled from 336 to 323 B.C.) took to conquering many foreign lands which included Persia, Judea, Syria, Mesopotamia, Egypt and others. He also conquered lands as far east as Punjab, India.
Before he died Alexander made military plans to expand into the Arabian peninsula, after which he would to turn his armies to the west (Carthage, Rome, and the Iberian Peninsula). His original vision had been to the east, though, to the ends of the world and the Great Outer Sea, as described by his boyhood tutor Aristotle. He died in the palace of Babylon's Nebuchadnezzar II in 323 B.C. His early death may have been brought about by poisoning, typhoid fever or possibly alcoholism. His legacy and conquests lived on long after him. His victories paved the way for the rise of Greek settlements and Greek cultural influence (Hellenistic Age) over distant areas.
God prophesied, through Daniel, the reign of this Greek conqueror and what would happen to his vast kingdom after his death (Daniel 8:21-22, 11:3-4). It was not passed to his sons nor was the kingdom ruled by any family member. Instead, it was divided up between his four chief generals (known in Biblical prophecy as "the four winds of heaven"). Within fifteen years of his death not one of Alexander's family remained alive.
His wife Statira was murdered by his other wife Roxana.
His brother Aridaeus, after ruling for slightly more than six years, was murdered along with his wife. The murder was carried out by order of his mother Olympias.
In retaliation for Aridaeus' death soldiers killed Olympias.
His son Alexander Aegus and mother Roxana were murdered by order of General Cassander.
The son and mother of Alexander the Great, Hercules and Barsine, were killed in private by Polysperchon.